A systematic review on Drug Re-profiling/Re-Purposing

Bharti Sharma; Dinesh Kumar Yadav

doi:10.51611/iars.irj.v12i02.2022.218

Authors

Bharti Sharma St. John's University
Dinesh Kumar Yadav Shree Guru Gobind Singh Tricentenary University

DOI:

https://doi.org/10.51611/iars.irj.v12i02.2022.218

Keywords:

Drug Repurposing, Medicine Strategies, COVID-19, Cancer, Orphan Diseases, General Medicine

Abstract

Hardcore capability of drug repurposing has allowed rising population of diversified diseased patients to approach various medications with known safety profiles. In an ongoing scenario considering current pharmaceutical market, we have numerous drugs that are approved and repurposed by the U.S. Food and Drug Administration. Developing and bringing a novel drug molecule from the laboratory to a market requires a lot of investment in terms of money, efforts, and time. On the other hand, repurposing a drug holds the capability of bringing out best cures with harmless, ease availability and inexpensive quality. Sildenafil, Chloroquine, Metformin are some examples of repurposed drug used in multiple disease models. Despite numerous challenges, drug repurposing stood to be a core component to any comprehensive drug re-discovering strategies which has been planned to bring benefit to the patients suffering from a wide variety of dreadful ailments. In this review, we have discussed the various repurposed drugs in numerous types of cancer, deadly novel coronavirus (SARS-CoV-2) and some orphan diseases. This paper holds various examples of drugs which are still under clinical trial and have high chances of being approved as repurposed drugs benefitting humankind.

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