Study of Metabolic Syndrome in Pre and Post Menopausal Women

Authors

DOI:

https://doi.org/10.51611/iars.irj.v12i02.2022.211

Keywords:

Medical Studies, Menopausal, Metabolic Syndrome

Abstract

Objective: The goal of this study was to determine the occurrence of metabolic disorder (MS) and its various components among pre-and postmenopausal women and their associated relationship between menopausal status and MS.

Materials and methods: The present study was conducted at the Biochemistry department in association with Obstetrics and Gynecology Department, Santosh Medical College and Hospital, Ghaziabad. The necessary approval was obtained from the institutional ethical committee to conduct the study and informed written consent was also obtained from the study subjects. The cross-sectional case-control study included premenopausal females aged between 20-40 years as the control group (n=41) postmenopausal females aged between 50-60 years as the case group (n=41).

Results: In the study group (post-menopause women), the mean value of BMI is 26.35±2.302 (kg/m2). In comparison with the control group (pre-menopause women), the mean value of BMI is 24.05±1.851 (kg/m2). There was a statically significant increase in the levels of BMI in the study group in comparison with the control group. There was a statically significant increase in the levels of SBP and DBP in the study group compared with the control group. In the study group, the mean value of FBS is 127.12±48.186 (mg/dl). In comparison with the control group (pre-menopause women), the mean value of FBS is 96.12±25.567 (mg/dl). There was a statically significant increase in the levels of FBS in the study group compared with the control group.

Conclusion: It has been concluded that MS was significantly more prevalent among postmenopausal women than premenopausal women. This indicates that they are at risk of developing hypertension, cardiovascular disease, and type 2 diabetes mellitus. Therefore, health care workers should closely monitor for the two conditions as metabolic syndrome is an underlying condition for other non-communicable diseases and also be advised to adopt healthy lifestyles to minimize the incidence of these conditions.

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References

Laufer LR, Gambone JC. Climacteric: menopause and peri- and postmenopause, Hacker and Moore's essentials of obstetrics and gynecology. 4th edition. Philadelphia: Saunders/Elsevier; 2004.

Lerner DJ, Kannel WB. Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population. Am Heart J. 1986 Feb;111(2):383-90. doi: 10.1016/0002-8703(86)90155-9 DOI: https://doi.org/10.1016/0002-8703(86)90155-9

Laufer LR, Gambone JC. Menstrual cycle-influenced disorders, Hacker and Moore's essentials of obstetrics and gynecology. 4th edition. Philadelphia: Saunders/Elsevier; 2004.

Schneider HP, Naftolin F. Climacteric medicine where do we go? : Proceedings of the 4th Workshop of the International Menopause Society. 1st edition London: Taylor & Francis; 2005. DOI: https://doi.org/10.3109/9780203024966

Eshtiaghi R, Esteghamati A, Nakhjavani M. Menopause is an independent predictor of metabolic syndrome in Iranian women. Maturitas. 2010 Mar;65(3):262-6. doi: 10.1016/j.maturitas.2009.11.004 DOI: https://doi.org/10.1016/j.maturitas.2009.11.004

Ginsberg HN. Insulin resistance and cardiovascular disease. J Clin Invest. 2000 Aug;106(4):453-8. doi: 10.1172/JCI10762. DOI: https://doi.org/10.1172/JCI10762

Longo DL, Kasper DL, Jameson JL, Fauci AS, Hauser SL, Loscalzo J. Harrison's Principles of Internal Medicine. 18th edition. New York: The McGraw-Hill Companies; 2012.

de Ferranti SD. Recovery from metabolic syndrome is both possible and beneficial. Clin Chem. 2010 Jul;56(7):1053-5. doi: 10.1373/clinchem.2010.146647 DOI: https://doi.org/10.1373/clinchem.2010.146647

Mendelsohn ME. Protective effects of estrogen on the cardiovascular system. Am J Cardiol. 2002 Jun 20;89(12A):12E-17E; discussion 17E-18E. doi: 10.1016/s0002-9149(02)02405-0 DOI: https://doi.org/10.1016/S0002-9149(02)02405-0

Qader SS, Shakir YA, Nyberg P, Samsioe G. Sociodemographic risk factors of metabolic syndrome in middle-aged women: results from a population-based study of Swedish women, The Women's Health in the Lund Area (WHILA) Study. Climacteric. 2008;11(6):475-82. doi: 10.1080/13697130802451787 DOI: https://doi.org/10.1080/13697130802451787

Misra A, Shrivastava U. Obesity and dyslipidemia in South Asians. Nutrients. 2013 Jul 16;5(7):2708-33. doi: 10.3390/nu5072708 DOI: https://doi.org/10.3390/nu5072708

Hamaguchi M, Kojima T, Ohbora A, Takeda N, Fukui M, Kato T. Aging is a risk factor of nonalcoholic fatty liver disease in premenopausal women. World J Gastroenterol. 2012 Jan 21;18(3):237-43. doi: 10.3748/wjg.v18.i3.237 DOI: https://doi.org/10.3748/wjg.v18.i3.237

Dowling NM, Gleason CE, Manson JE, Hodis HN, Miller VM, Brinton EA, et al. Characterization of vascular disease risk in postmenopausal women and its association with cognitive performance. PLoS One. 2013 Jul 17;8(7):e68741. doi: 10.1371/journal.pone.0068741 DOI: https://doi.org/10.1371/journal.pone.0068741

Ruan X, Jin J, Hua L, Liu Y, Wang J, Liu S. The prevalence of metabolic syndrome in Chinese postmenopausal women and the optimum body composition indices to predict it. Menopause. 2010 May-Jun;17(3):566-70. doi: 10.1097/gme.0b013e3181c8f4e1. DOI: https://doi.org/10.1097/gme.0b013e3181c8f4e1

Reaven G. The metabolic syndrome or the insulin resistance syndrome? Different names, different concepts, and different goals. Endocrinol Metab Clin North Am. 2004 Jun;33(2):283-303. doi: 10.1016/j.ecl.2004.03.002. DOI: https://doi.org/10.1016/j.ecl.2004.03.002

Isles CG, Hole DJ, Hawthorne VM, Lever AF. Relation between coronary risk and coronary mortality in women of the Renfrew and Paisley survey: comparison with men. Lancet. 1992 Mar 21;339(8795):702-6. doi: 10.1016/0140-6736(92)90599-x DOI: https://doi.org/10.1016/0140-6736(92)90599-X

Gohlke-Bärwolf C. Coronary artery disease--is menopause a risk factor? Basic Res Cardiol. 2000;95 Suppl 1:I77-83. doi: 10.1007/s003950070014. DOI: https://doi.org/10.1007/s003950070014

Baker L, Meldrum KK, Wang M, Sankula R, Vanam R, Raiesdana A, et al. The role of estrogen in cardiovascular disease. J Surg Res. 2003 Dec;115(2):325-44. doi: 10.1016/s0022-4804(03)00215-4. DOI: https://doi.org/10.1016/S0022-4804(03)00215-4

Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol. 2000 Dec;279(6):L1005-28. doi: 10.1152/ajplung.2000.279.6.L1005. DOI: https://doi.org/10.1152/ajplung.2000.279.6.L1005

Li Y, Wei FF, Wang S, Cheng YB, Wang JG. Cardiovascular risks associated with diastolic blood pressure and isolated diastolic hypertension. Curr Hypertens Rep. 2014 Nov;16(11):489. doi: 10.1007/s11906-014-0489-x. DOI: https://doi.org/10.1007/s11906-014-0489-x

Published

2022-08-29

Issue

Section

Peer Reviewed Research Manuscript

How to Cite

Singh, M. (2022) “Study of Metabolic Syndrome in Pre and Post Menopausal Women”, IARS’ International Research Journal, 12(02). doi:10.51611/iars.irj.v12i02.2022.211.

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